Endocrine Abstracts

Acromegaly is a rare disease characterised by excessive Growth Hormone production. Subfertility is common in acromegaly and has various aetiologies, therefore pregnancy in acromegaly is rare. The limited data that is available would suggest that pregnancy in acromegaly is generally safe. However, there have been reports of tumour expansion during pregnancy. Here we present a case of first presentation of acromegaly in pregnancy and subsequent rescue of visual field loss with s...

Patients with adrenal insufficiency (AI) should be informed about ‘sick day rules’ and risk of a life-threatening adrenal crisis if corticosteroids are abruptly stopped or if the steroid dose is inadequate.Aims and Methods: To assess current practice with regard to steroid advice given across medical specialties at Oxford University Hospital Trust. To assess patient knowledge both in a specialist Endocrine department and in a medical specialty ...

A 24 year old man presented with gait instability, myalgia, and cognitive decline, after a holiday in Crete; his alcohol intake exceeded 200 units/week. He had marked facial dysmorphism, with frontal bossing, and global muscle weakness. He had hypernatraemic dehydration (plasma sodium 175 mmol/l urea 16.9 mmol/l), but denied thirst. Urine concentration was 894 mOsm/kg, excluding diabetes insipidus. CK was elevated at 15,540 U/l. CT brain shown marked hydrocephalus. Rhabdomyoly...

Background: Primary aldosteronism (PA) is the commonest cause of secondary hypertension. Reported prevalence is about 30% in hypertensive population. Success of screening for PA in general practice (GP) is unknown. Expected challenges include laboratory access, transport issues and interfering medications.Aims: We aimed to report prevalence of PA in a large primary care cohort, the correlation between GP and in-hospital ARR and to assess if a change in r...